Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.

Gannavaram, Sreenivas; Torcivia, John; Gasparyan, Lusine; Kaul, Amit; Ismail, Nevien; Simonyan, Vahan; Nakhasi, Hira L

Gannavaram, Sreenivas; Torcivia, John; Gasparyan, Lusine; Kaul, Amit; Ismail, Nevien; Simonyan, Vahan; Nakhasi, Hira L.

Afiliación

Gannavaram S; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. sreenivas.gannavaram@fda.hhs.gov.
Torcivia J; High Performance Integrated Virtual Environment, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Gasparyan L; DNA-HIVE, Rockville, 20850, MD, United States.
Kaul A; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Ismail N; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Simonyan V; High Performance Integrated Virtual Environment, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. vahan.simonyan@fda.hhs.gov.
Nakhasi HL; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. hira.nakhasi@fda.hhs.gov.

Sci Rep ; 7(1): 4718, 2017 07 05.

Article en En | MEDLINE | ID: mdl-28680050

Asunto(s)

Leishmania donovani/genética; Vacunas Atenuadas/genética; Secuenciación Completa del Genoma/métodos; Biología Computacional/métodos; Marcadores Genéticos; Genoma de Protozoos; Humanos; Vacunas Antiprotozoos/genética; Eliminación de Secuencia

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leishmania donovani / Vacunas Atenuadas / Secuenciación Completa del Genoma Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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