ATP synthase-mediated proton fluxes and phosphorylation in rat liver mitochondria: dependence on delta mu H.
Biochim Biophys Acta
; 851(1): 123-35, 1986 Aug 13.
Article
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| MEDLINE
| ID: mdl-2873837
ABSTRACT
The dependence of the proton flux through the ATP synthases of rat liver mitochondria on a driving force composed mainly of a potassium diffusion potential was determined and compared with the relationship between rate of phosphorylation and delta mu H given by titrations with the respiratory inhibitor malonate. The two functions are in good agreement in the lower part of the delta mu H range covered. However, the maximal proton fluxes through the ATP synthases are much lower than needed to account for the rate of State 3 phosphorylation sustained by the same mitochondria oxidizing succinate. Possible reasons for this behavior are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
/
Mitocondrias Hepáticas
/
ATPasas de Translocación de Protón
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1986
Tipo del documento:
Article