Modulation of the extent of structural heterogeneity in &#945;-synuclein fibrils by the small molecule thioflavin T.

Kumar, Harish; Singh, Jogender; Kumari, Pratibha; Udgaonkar, Jayant B

Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T.

Kumar, Harish; Singh, Jogender; Kumari, Pratibha; Udgaonkar, Jayant B.

Afiliación

Kumar H; From the National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.
Singh J; From the National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.
Kumari P; the Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, and.
Udgaonkar JB; From the National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.

J Biol Chem ; 292(41): 16891-16903, 2017 10 13.

Article en En | MEDLINE | ID: mdl-28760825

Asunto(s)

Complejos Multiproteicos/química; Agregación Patológica de Proteínas; Multimerización de Proteína; Tiazoles/química; alfa-Sinucleína/química; Benzotiazoles; Humanos

Palabras clave

alpha-synuclein (α-synuclein); atomic force microscopy (AFM); fibril heterogeneity; hydrogen exchange mass spectrometry; neurodegenerative disease; thioflavin T; toxicity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiazoles / Complejos Multiproteicos / Alfa-Sinucleína / Multimerización de Proteína / Agregación Patológica de Proteínas Límite: Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article País de afiliación: India

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