Fertility Preservation in Endometriosis Patients: Anti-Müllerian Hormone Is a Reliable Marker of the Ovarian Follicle Density.
Front Surg
; 4: 40, 2017.
Article
en En
| MEDLINE
| ID: mdl-28791295
ABSTRACT
OBJECTIVE:
To analyze the ovarian reserve via measurement of follicular density and anti-Müllerian hormone (AMH) in endometriosis patients participating to a clinical program of cortical ovarian cryopreservation.DESIGN:
Retrospective analysis of serum AMH levels and prospective investigation of ovarian follicle number.SETTING:
University Hospital. PATIENTS Two hundred and two women with endometriosis and 400 controls.INTERVENTIONS:
Blood samples and ovarian biopsies. MAIN OUTCOMEMEASURES:
Correlation of serum AMH levels and the number of non-growing follicles in the biopsied cortical tissues in endometriosis and control subjects, including age, type of AMH kit, and the laboratory performing the analysis as covariates.RESULTS:
AMH levels were shown to decrease with age in untreated endometriosis patients (P < 1.0 × 10-5) but they were significantly lower in endometriosis compared to controls only in patients over 36 years old (P = 2.7 × 10-4). The AMH decrease was faster in endometriosis compared to controls (beta = 0.27, P = 4.0 × 10-4). Primordial follicle number decreased with the reduction of AMH levels in both cases and controls (beta = 0.3; P = 0.04).CONCLUSION:
AMH is a reliable marker of ovarian reserve in endometriosis patients, and it can predict follicular density in women undergoing ovarian tissue cryopreservation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Front Surg
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia