Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors.

Jin, Yafei; Huang, Xiaoqin; Papke, Roger L; Jutkiewicz, Emily M; Showalter, Hollis D; Zhan, Chang-Guo

Jin, Yafei; Huang, Xiaoqin; Papke, Roger L; Jutkiewicz, Emily M; Showalter, Hollis D; Zhan, Chang-Guo.

Afiliación

Jin Y; Department of Medicinal Chemistry and Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States.
Huang X; Department of Pharmaceutical Sciences and Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States.
Papke RL; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, United States.
Jutkiewicz EM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States.
Showalter HD; Department of Medicinal Chemistry and Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: showalh@umich.edu.
Zhan CG; Department of Pharmaceutical Sciences and Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States. Electronic address: zhan@uky.edu.

Bioorg Med Chem Lett ; 27(18): 4350-4353, 2017 09 15.

Article en En | MEDLINE | ID: mdl-28838693

Asunto(s)

Diseño de Fármacos; Antagonistas Nicotínicos/farmacología; Piridinas/farmacología; Receptores Nicotínicos/metabolismo; Animales; Relación Dosis-Respuesta a Droga; Humanos; Modelos Moleculares; Estructura Molecular; Antagonistas Nicotínicos/síntesis química; Antagonistas Nicotínicos/química; Piridinas/síntesis química; Piridinas/química; Ratas; Relación Estructura-Actividad

Palabras clave

Acetylcholine receptor; Antagonist design; Nicotine; Organic synthesis; Selective antagonist

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Diseño de Fármacos / Receptores Nicotínicos / Antagonistas Nicotínicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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