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Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.
Teague, W Gerald; Phillips, Brenda R; Fahy, John V; Wenzel, Sally E; Fitzpatrick, Anne M; Moore, Wendy C; Hastie, Annette T; Bleecker, Eugene R; Meyers, Deborah A; Peters, Stephen P; Castro, Mario; Coverstone, Andrea M; Bacharier, Leonard B; Ly, Ngoc P; Peters, Michael C; Denlinger, Loren C; Ramratnam, Sima; Sorkness, Ronald L; Gaston, Benjamin M; Erzurum, Serpil C; Comhair, Suzy A A; Myers, Ross E; Zein, Joe; DeBoer, Mark D; Irani, Anne-Marie; Israel, Elliot; Levy, Bruce; Cardet, Juan Carlos; Phipatanakul, Wanda; Gaffin, Jonathan M; Holguin, Fernando; Fajt, Merritt L; Aujla, Shean J; Mauger, David T; Jarjour, Nizar N.
Afiliación
  • Teague WG; University of Virginia School of Medicine, Charlottesville, Va. Electronic address: wgt2p@virginia.edu.
  • Phillips BR; Pennsylvania State University School of Medicine, Hershey, Pa.
  • Fahy JV; University of California, San Francisco School of Medicine, San Francisco, Calif.
  • Wenzel SE; University of Pittsburgh School of Medicine, Pittsburgh, Pa.
  • Fitzpatrick AM; Emory University School of Medicine, Atlanta, Ga.
  • Moore WC; Wake Forest University School of Medicine, Winston-Salem, NC.
  • Hastie AT; Wake Forest University School of Medicine, Winston-Salem, NC.
  • Bleecker ER; Wake Forest University School of Medicine, Winston-Salem, NC.
  • Meyers DA; Wake Forest University School of Medicine, Winston-Salem, NC.
  • Peters SP; Wake Forest University School of Medicine, Winston-Salem, NC.
  • Castro M; Washington University School of Medicine, St. Louis, Mo.
  • Coverstone AM; Washington University School of Medicine, St. Louis, Mo.
  • Bacharier LB; Washington University School of Medicine, St. Louis, Mo.
  • Ly NP; University of California, San Francisco School of Medicine, San Francisco, Calif.
  • Peters MC; University of California, San Francisco School of Medicine, San Francisco, Calif.
  • Denlinger LC; University of Wisconsin School of Medicine, Madison, Wis.
  • Ramratnam S; University of Wisconsin School of Medicine, Madison, Wis.
  • Sorkness RL; University of Wisconsin School of Medicine, Madison, Wis.
  • Gaston BM; Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • Erzurum SC; Cleveland Clinic School of Medicine, Cleveland, Ohio.
  • Comhair SAA; Cleveland Clinic School of Medicine, Cleveland, Ohio.
  • Myers RE; Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • Zein J; Cleveland Clinic School of Medicine, Cleveland, Ohio.
  • DeBoer MD; University of Virginia School of Medicine, Charlottesville, Va.
  • Irani AM; Virginia Commonwealth University School of Medicine, Richmond, Va.
  • Israel E; Harvard University School of Medicine, Boston, Mass.
  • Levy B; Harvard University School of Medicine, Boston, Mass.
  • Cardet JC; Harvard University School of Medicine, Boston, Mass.
  • Phipatanakul W; Harvard University School of Medicine, Boston, Mass.
  • Gaffin JM; Harvard University School of Medicine, Boston, Mass.
  • Holguin F; University of Pittsburgh School of Medicine, Pittsburgh, Pa.
  • Fajt ML; University of Pittsburgh School of Medicine, Pittsburgh, Pa.
  • Aujla SJ; University of Pittsburgh School of Medicine, Pittsburgh, Pa.
  • Mauger DT; Pennsylvania State University School of Medicine, Hershey, Pa.
  • Jarjour NN; University of Wisconsin School of Medicine, Madison, Wis.
J Allergy Clin Immunol Pract ; 6(2): 545-554.e4, 2018.
Article en En | MEDLINE | ID: mdl-28866107
ABSTRACT

BACKGROUND:

The effect of age on asthma severity is poorly understood.

OBJECTIVES:

The objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features.

METHODS:

SARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma. The sample included 188 children (111 severe, 77 nonsevere) and 526 adults (313 severe, 213 nonsevere) characterized for demographic features, symptoms, health care utilization, lung function, and inflammatory markers compared by age and severity.

RESULTS:

Compared with children with nonsevere asthma, children with severe asthma had more symptoms and more historical exacerbations, but no difference in body weight, post-bronchodilator lung function, or inflammatory markers. After childhood, and increasing with age, the cohort had a higher proportion of women, less allergen sensitization, and overall fewer blood eosinophils. Enrollment of participants with severe asthma was highest in middle-aged adults, who were older, more obese, with greater airflow limitation and higher blood eosinophils, but less allergen sensitization than adults with nonsevere asthma.

CONCLUSIONS:

The phenotypic features of asthma differ by severity and with advancing age. With advancing age, patients with severe asthma are more obese, have greater airflow limitation, less allergen sensitization, and variable type 2 inflammation. Novel mechanisms besides type 2 inflammatory pathways may inform the severe asthma phenotype with advancing age.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2018 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2018 Tipo del documento: Article