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Atypical PKC, PKCλ/ι, activates ß-secretase and increases Aß1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
Sajan, Mini P; Hansen, Barbara C; Higgs, Margaret G; Kahn, C Ron; Braun, Ursula; Leitges, Michael; Park, Collin R; Diamond, David M; Farese, Robert V.
Afiliación
  • Sajan MP; Internal Medicine and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida, USA; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, USA.
  • Hansen BC; Internal Medicine and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida, USA.
  • Higgs MG; Internal Medicine and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida, USA.
  • Kahn CR; Joslin Research Foundation, Harvard Medical School, Boston, MA, USA.
  • Braun U; Biotechnology Centre of Oslo, Oslo, Norway.
  • Leitges M; Biotechnology Centre of Oslo, Oslo, Norway.
  • Park CR; Departments of Psychology, Molecular Pharmacology and Physiology, Center for Preclinical and Clinical Research on PTSD, University of South Florida, Tampa, Florida, USA.
  • Diamond DM; Departments of Psychology, Molecular Pharmacology and Physiology, Center for Preclinical and Clinical Research on PTSD, University of South Florida, Tampa, Florida, USA.
  • Farese RV; Internal Medicine and Research Services, James A. Haley Veterans Medical Center, Tampa, Florida, USA; Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, USA. Electronic address: rfarese@health.usf.edu.
Neurobiol Aging ; 61: 225-237, 2018 01.
Article en En | MEDLINE | ID: mdl-29032894
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Encéfalo / Proteína Quinasa C / Péptidos beta-Amiloides / Proteínas tau / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Hiperinsulinismo / Isoenzimas / Memoria Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Encéfalo / Proteína Quinasa C / Péptidos beta-Amiloides / Proteínas tau / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Hiperinsulinismo / Isoenzimas / Memoria Límite: Animals Idioma: En Revista: Neurobiol Aging Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos