Antagonism of the responses to isoproterenol in the rat hippocampal slice with subtype-selective antagonists.
Eur J Pharmacol
; 153(1): 105-10, 1988 Aug 09.
Article
en En
| MEDLINE
| ID: mdl-2905663
ABSTRACT
The electrophysiological and cAMP responses to the beta-adrenoceptor agonist isoproterenol were measured in the in vitro hippocampal slice preparation. Subtype-selective antagonists were used to evaluate the specificity of these responses. The beta 1-selective antagonist ICI 89,406 was 60-fold more potent than was the beta 2-selective antagonist ICI 118,551 at antagonizing the electrophysiological response. ICI 89,406 was 200 times more potent in its antagonism of the cAMP response. These results suggest that the electrophysiological and cAMP responses in this preparation are primarily mediated by beta 1-adrenoceptors.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipocampo
/
Isoproterenol
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1988
Tipo del documento:
Article