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Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
Michelakis, Evangelos D; Gurtu, Vikram; Webster, Linda; Barnes, Gareth; Watson, Geoffrey; Howard, Luke; Cupitt, John; Paterson, Ian; Thompson, Richard B; Chow, Kelvin; O'Regan, Declan P; Zhao, Lan; Wharton, John; Kiely, David G; Kinnaird, Adam; Boukouris, Aristeidis E; White, Chris; Nagendran, Jayan; Freed, Darren H; Wort, Stephen J; Gibbs, J Simon R; Wilkins, Martin R.
Afiliación
  • Michelakis ED; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada. em2@ualberta.ca m.wilkins@imperial.ac.uk.
  • Gurtu V; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Webster L; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Barnes G; Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Watson G; Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Howard L; National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
  • Cupitt J; Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Paterson I; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Thompson RB; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Chow K; Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • O'Regan DP; Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK.
  • Zhao L; Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Wharton J; Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Kiely DG; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
  • Kinnaird A; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Boukouris AE; Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • White C; Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Nagendran J; Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Freed DH; Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  • Wort SJ; National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
  • Gibbs JSR; National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
  • Wilkins MR; Department of Medicine, Imperial College London, London W12 0NN, UK. em2@ualberta.ca m.wilkins@imperial.ac.uk.
Sci Transl Med ; 9(413)2017 Oct 25.
Article en En | MEDLINE | ID: mdl-29070699
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Predisposición Genética a la Enfermedad / Inhibidores de Proteínas Quinasas / Hipertensión Pulmonar Primaria Familiar Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Predisposición Genética a la Enfermedad / Inhibidores de Proteínas Quinasas / Hipertensión Pulmonar Primaria Familiar Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article