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Neural correlates of working memory deficits and associations to response inhibition in obsessive compulsive disorder.
Heinzel, Stephan; Kaufmann, Christian; Grützmann, Rosa; Hummel, Robert; Klawohn, Julia; Riesel, Anja; Bey, Katharina; Lennertz, Leonhard; Wagner, Michael; Kathmann, Norbert.
Afiliación
  • Heinzel S; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany; Clinical Psychology and Psychotherapy, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany. Electronic address: stephan.heinzel@fu-berlin.de.
  • Kaufmann C; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
  • Grützmann R; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
  • Hummel R; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
  • Klawohn J; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
  • Riesel A; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
  • Bey K; Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany; DZNE, German Center for Neurodegenerative Diseases, Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
  • Lennertz L; Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
  • Wagner M; Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany; DZNE, German Center for Neurodegenerative Diseases, Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
  • Kathmann N; Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany.
Neuroimage Clin ; 17: 426-434, 2018.
Article en En | MEDLINE | ID: mdl-29159055
Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empirical evidence for a proposed conceptual link to inhibition deficits is missing. We investigated WM performance in a numeric n-back task with four WM load conditions during functional Magnetic Resonance Imaging (fMRI) in 51 patients with OCD and 49 healthy control participants who were matched for age, sex, and education. Additionally, a stop signal task was performed outside the MRI scanner in a subsample. On the behavioral level, a significant WM load by group interaction was found for both accuracy (p < 0.02) and reaction time measures (p < 0.03), indicating increased reaction times as well as reduced accuracy specifically at high WM load (3-back) in patients with OCD. Whole-brain analyses of fMRI-data identified neural correlates of a load-dependent WM decrement in OCD in the supplementary motor area (SMA) and the inferior parietal lobule (IPL). Within the OCD sample, SMA-activity as well as n-back performance were correlated with stop signal task performance. Results from behavioral and fMRI-analyses indicate a reduced WM load-dependent modulation of neural activity in OCD and suggest a common neural mechanism for inhibitory dysfunction and WM decrements in OCD.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Inhibición Psicológica / Trastornos de la Memoria / Memoria a Corto Plazo / Trastorno Obsesivo Compulsivo Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Clin Año: 2018 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Inhibición Psicológica / Trastornos de la Memoria / Memoria a Corto Plazo / Trastorno Obsesivo Compulsivo Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Clin Año: 2018 Tipo del documento: Article