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Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
Mohsin, Noor-Ul-Amin; Seebacher, Werner; Faist, Johanna; Hochegger, Patrick; Kaiser, Marcel; Mäser, Pascal; Belaj, Ferdinand; Saf, Robert; Kretschmer, Nadine; Alajlani, Muaaz; Turek, Ivana; Brantner, Adelheid; Bauer, Rudolf; Bucar, Franz; Weis, Robert.
Afiliación
  • Mohsin NU; Faculty of Pharmaceutical Sciences, Government College University, Allama Iqbal Road, 38000 Faisalabad, Pakistan; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
  • Seebacher W; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria. Electronic address: we.seebacher@uni-graz.at.
  • Faist J; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
  • Hochegger P; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
  • Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Mäser P; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Belaj F; Institute of Chemistry, University of Graz, Universitätsplatz 1, 8010 Graz, Austria.
  • Saf R; Institute for Chemistry and Technology of Organic Materials (ICTM), Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.
  • Kretschmer N; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Alajlani M; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Turek I; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Brantner A; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Bauer R; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Bucar F; Institute of Pharmaceutical Sciences, Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Graz, Austria.
  • Weis R; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
Eur J Med Chem ; 143: 97-106, 2018 Jan 01.
Article en En | MEDLINE | ID: mdl-29172086
ABSTRACT
A series of N-benzyl tetrahydropiperidinylidene pyrrolidinium salts have been synthesized and investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxic effects. The antibacterial, antimycobacterial and anticancer potencies of selected compounds were examined, too. Physicochemical parameters were calculated and structure-activity-relationships are discussed.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Compuestos de Bencilo / Compuestos de Amonio Cuaternario / Antibacterianos / Antifúngicos / Antineoplásicos / Antiprotozoarios Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Compuestos de Bencilo / Compuestos de Amonio Cuaternario / Antibacterianos / Antifúngicos / Antineoplásicos / Antiprotozoarios Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Austria