Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts.

Drebert, Zuzanna; De Vlieghere, Elly; Bridelance, Jolien; De Wever, Olivier; De Bosscher, Karolien; Bracke, Marc; Beck, Ilse M

Drebert, Zuzanna; De Vlieghere, Elly; Bridelance, Jolien; De Wever, Olivier; De Bosscher, Karolien; Bracke, Marc; Beck, Ilse M.

Afiliación

Drebert Z; Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
De Vlieghere E; Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Bridelance J; Molecular Signaling and Cell Death Unit, VIB Center for Inflammation Research, Ghent University, Ghent, Belgium.
De Wever O; Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
De Bosscher K; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Receptor Research Laboratories, Nuclear Receptor Lab, VIB Center for Medical Biotechnology, Department of Biochemistry, Ghent University, Ghent, Belgium.
Bracke M; Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Beck IM; Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department Health Sciences, Odisee University College, Ghent, Belgium. Electronic address: Ilse.B

Exp Cell Res ; 362(2): 332-342, 2018 01 15.

Article en En | MEDLINE | ID: mdl-29196164

Asunto(s)

Fibroblastos Asociados al Cáncer/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Neoplasias del Colon/tratamiento farmacológico; Glucocorticoides/administración & dosificación; Animales; Fibroblastos Asociados al Cáncer/patología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Técnicas de Cocultivo; Neoplasias del Colon/genética; Neoplasias del Colon/patología; Dexametasona/administración & dosificación; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Factor de Crecimiento de Hepatocito/genética; Humanos; Metaloproteinasa 2 de la Matriz/genética; Invasividad Neoplásica/genética; Invasividad Neoplásica/patología; Tenascina/genética

Palabras clave

Cancer cell invasion; Cancer cell proliferation; Cancer-associated fibroblasts (CAFs); Colon cancer; Glucocorticoids

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias del Colon / Proliferación Celular / Fibroblastos Asociados al Cáncer / Glucocorticoides Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Exp Cell Res Año: 2018 Tipo del documento: Article País de afiliación: Bélgica

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