Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (<i>SLFN11)</i> Expression with Class I Histone Deacetylase Inhibitors.

Tang, Sai-Wen; Thomas, Anish; Murai, Junko; Trepel, Jane B; Bates, Susan E; Rajapakse, Vinodh N; Pommier, Yves

Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors.

Tang, Sai-Wen; Thomas, Anish; Murai, Junko; Trepel, Jane B; Bates, Susan E; Rajapakse, Vinodh N; Pommier, Yves.

Afiliación

Tang SW; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Thomas A; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Murai J; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Trepel JB; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Bates SE; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Rajapakse VN; Division of Hematology/Oncology, Columbia University, New York, New York.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

Clin Cancer Res ; 24(8): 1944-1953, 2018 04 15.

Article en En | MEDLINE | ID: mdl-29391350

Asunto(s)

Resistencia a Antineoplásicos/genética; Epigénesis Genética/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Inhibidores de Histona Desacetilasas/farmacología; Proteínas Nucleares/genética; Camptotecina/farmacología; Línea Celular Tumoral; Daño del ADN/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Sinergismo Farmacológico; Humanos; Inhibidores de Topoisomerasa I/farmacología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Nucleares / Regulación Neoplásica de la Expresión Génica / Resistencia a Antineoplásicos / Epigénesis Genética / Inhibidores de Histona Desacetilasas Límite: Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article

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