Severe post-artesunate delayed onset anaemia responding to corticotherapy: a case report.

Lebrun, Delphine; Floch, Thierry; Brunet, Aurélie; Julien, Gautier; Romaru, Juliette; N'Guyen, Yohan; Cousson, Joël; Giltat, Aurélien; Toubas, Dominique; Bani-Sadr, Firouzé

Lebrun, Delphine; Floch, Thierry; Brunet, Aurélie; Julien, Gautier; Romaru, Juliette; N'Guyen, Yohan; Cousson, Joël; Giltat, Aurélien; Toubas, Dominique; Bani-Sadr, Firouzé.

Afiliación

Lebrun D; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Floch T; Department of Internal Medicine and Infectious Diseases, Manchester Hospital, Charleville-Mézières, France.
Brunet A; Intensive Care Unit, Reims Teaching Hospitals, Reims, France.
Julien G; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Romaru J; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
N'Guyen Y; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Cousson J; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Giltat A; Intensive Care Unit, Reims Teaching Hospitals, Reims, France.
Toubas D; Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims Teaching Hospitals, Reims, France.
Bani-Sadr F; Parasitology-Mycology Laboratory, Reims Teaching Hospitals, Reims, France.

J Travel Med ; 25(1)2018 01 01.

Article en En | MEDLINE | ID: mdl-29394387

RESUMEN

Delayed onset haemolysis occurring post-artesunate and post-artemisinin combination therapy is secondary to delayed clearance of infected erythrocytes spared by pitting during treatment. We report a case of severe post-treatment delayed haemolytic anaemia with a positive direct antiglobulin test and a positive response to corticosteroid therapy, suggesting an associated immune mechanism.

Asunto(s)

Anemia Hemolítica/tratamiento farmacológico; Artemisininas/uso terapéutico; Artesunato/uso terapéutico; Malaria Falciparum/tratamiento farmacológico; Parasitemia/tratamiento farmacológico; Administración Intravenosa; Corticoesteroides/uso terapéutico; Adulto; Anemia Hemolítica/parasitología; Prueba de Coombs; Hemólisis/efectos de los fármacos; Humanos; Malaria Falciparum/complicaciones; Masculino; Parasitemia/complicaciones; Viaje

Palabras clave

Post-artesunate delayed onset anaemia; autoimmune haemolysis; pitting; post-artemisin delayed onset haemolysis; post-artesunate delayed onset haemolysis; severe malaria

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Malaria Falciparum / Parasitemia / Artemisininas / Artesunato / Anemia Hemolítica Límite: Adult / Humans / Male Idioma: En Revista: J Travel Med Asunto de la revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Año: 2018 Tipo del documento: Article País de afiliación: Francia

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