Dopamine receptors: homomeric and heteromeric complexes in L-DOPA-induced dyskinesia.
J Neural Transm (Vienna)
; 125(8): 1187-1194, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29417335
ABSTRACT
The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using L-3,4-dihydroxyphenylalanine (L-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as L-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R-D3R heteromers. Interestingly, there is a correlation between the expression of D1R-D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Dopamina D1
/
Discinesia Inducida por Medicamentos
/
Receptores de Dopamina D3
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
2018
Tipo del documento:
Article
País de afiliación:
España