Acidic organelles mediate TGF-ß1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells.

Oba-Yabana, Ikuko; Mori, Takefumi; Takahashi, Chika; Hirose, Takuo; Ohsaki, Yusuke; Kinugasa, Satoshi; Muroya, Yoshikazu; Sato, Emiko; Nguyen, Geneviève; Piedagnel, Rémi; Ronco, Pierre M; Totsune, Kazuhito; Ito, Sadayoshi

Oba-Yabana, Ikuko; Mori, Takefumi; Takahashi, Chika; Hirose, Takuo; Ohsaki, Yusuke; Kinugasa, Satoshi; Muroya, Yoshikazu; Sato, Emiko; Nguyen, Geneviève; Piedagnel, Rémi; Ronco, Pierre M; Totsune, Kazuhito; Ito, Sadayoshi.

Afiliación

Oba-Yabana I; Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Mori T; Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Takahashi C; Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. tmori@hosp.tohoku-mpu.ac.jp.
Hirose T; Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. tmori@hosp.tohoku-mpu.ac.jp.
Ohsaki Y; Division of Integrated Renal Replacement Therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kinugasa S; Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Muroya Y; Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Sato E; Center for Interdisciplinary Research in Biology, Collège de France, Paris, France.
Nguyen G; Division of Integrated Renal Replacement Therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.
Piedagnel R; Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Ronco PM; Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Totsune K; Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ito S; Center for Interdisciplinary Research in Biology, Collège de France, Paris, France.

Sci Rep ; 8(1): 2648, 2018 02 08.

Article en En | MEDLINE | ID: mdl-29422602

Asunto(s)

Orgánulos/metabolismo; Fibrosis Peritoneal/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Anciano; Animales; Movimiento Celular/efectos de los fármacos; Soluciones para Diálisis/metabolismo; Epitelio/metabolismo; Femenino; Fibrosis/metabolismo; Fibrosis/patología; Glucosa/metabolismo; Humanos; Concentración de Iones de Hidrógeno; Riñón/metabolismo; Masculino; Persona de Mediana Edad; Cavidad Peritoneal/fisiología; Diálisis Peritoneal/efectos adversos; Diálisis Peritoneal/métodos; Fibrosis Peritoneal/patología; Peritoneo/metabolismo; Transporte de Proteínas; Ratas; Ratas Wistar; Receptores de Superficie Celular/metabolismo; Renina/metabolismo; ATPasas de Translocación de Protón Vacuolares/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Orgánulos / Factor de Crecimiento Transformador beta1 / Fibrosis Peritoneal Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Japón

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