Conserved cysteines in the finger domain of the epithelial Na<sup>+</sup> channel &#945; and Î³ subunits are proximal to the dynamic finger-thumb domain interface.

Blobner, Brandon M; Wang, Xue-Ping; Kashlan, Ossama B

Conserved cysteines in the finger domain of the epithelial Na⁺ channel α and Î³ subunits are proximal to the dynamic finger-thumb domain interface.

Blobner, Brandon M; Wang, Xue-Ping; Kashlan, Ossama B.

Afiliación

Blobner BM; Departments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261.
Wang XP; Departments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261.
Kashlan OB; Departments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261; Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. Electronic address: obk2@pitt.edu.

J Biol Chem ; 293(13): 4928-4939, 2018 03 30.

Article en En | MEDLINE | ID: mdl-29425099

Asunto(s)

Canales Epiteliales de Sodio/química; Animales; Cisteína/química; Cisteína/genética; Cisteína/metabolismo; Canales Epiteliales de Sodio/genética; Canales Epiteliales de Sodio/metabolismo; Humanos; Dominios Proteicos; Xenopus laevis

Palabras clave

allosteric regulation; cysteine-mediated crosslinking; epithelial sodium channel (ENaC); protein conformation; reactive oxygen species (ROS)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Canales Epiteliales de Sodio Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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