Chemokines and receptors in intestinal B lymphocytes.
J Leukoc Biol
; 103(5): 807-819, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29443417
ABSTRACT
Recent studies indicate that chemoattractant cytokines (chemokines) and their receptors modulate intestinal B lymphocytes in different ways, including regulating their maturity and differentiation in the bone marrow and homing to intestinal target tissues. Here, we review several important chemokine/chemokine receptor axes that guide intestinal B cells, focusing on the homing and migration of IgA antibody-secreting cells (IgA-ASCs) to intestinal-associated lymphoid tissues. We describe the selective regulation of these chemokine axes in coordinating the IgA-ASC trafficking in intestinal diseases. Finally, we discuss the role of B cells as chemokine producers serving dual roles in regulating the mucosal immune microenvironment.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Quimiocinas
/
Receptores de Quimiocina
/
Intestinos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Leukoc Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
China