Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

Verma, Ajeet Kumar; Yadav, Arti; Singh, Sarvendra Vikram; Mishra, Pratibha; Rath, Srikanta Kumar

Verma, Ajeet Kumar; Yadav, Arti; Singh, Sarvendra Vikram; Mishra, Pratibha; Rath, Srikanta Kumar.

Afiliación

Verma AK; PCS 103 Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Molecular Biprospection Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Near Kukrail P
Yadav A; PCS 103 Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Singh SV; PCS 103 Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Mishra P; PCS 103 Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Rath SK; PCS 103 Genotoxicity Lab, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. Electronic address: skrath@cdri.res.in.

Life Sci ; 199: 23-33, 2018 Apr 15.

Article en En | MEDLINE | ID: mdl-29499281

Asunto(s)

Apoptosis/efectos de los fármacos; Isoniazida/toxicidad; Factor 2 Relacionado con NF-E2/antagonistas & inhibidores; Estrés Oxidativo/efectos de los fármacos; Animales; Antituberculosos/toxicidad; Apoptosis/fisiología; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/fisiología; Células Hep G2; Humanos; Ratones; Ratones Endogámicos BALB C; Factor 2 Relacionado con NF-E2/fisiología; Estrés Oxidativo/fisiología

Palabras clave

Cell-cycle analysis; Hepatotoxicity; Immunocytochemistry; Isoniazid; Karyopherin ß1; Nrf2

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Estrés Oxidativo / Factor 2 Relacionado con NF-E2 / Isoniazida Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Life Sci Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google