Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.
J Exp Med
; 165(6): 1459-67, 1987 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-2953844
ABSTRACT
Human rIL-4 is able to induce the expression of low-affinity receptors for IgE (Fc epsilon RL/CD23) on resting B lymphocytes, as determined by the binding of either the anti Fc epsilon RL/CD23-specific mAb 25 or IgE. Stimulation of B cells with insolubilized anti-IgM antibody increases the number of cells expressing Fc epsilon RL/CD23 upon culturing with IL-4 and enhances the level of Fc epsilon RL/CD23 expression on these cells. Fc epsilon RL/CD23 induction is specific for IL-4 since IL-1 alpha, IL-2, IFN-gamma, B cell-derived B cell growth factor (BCGF), and a low-molecular-weight BCGF were ineffective. IFN-gamma strongly inhibited the induction of Fc epsilon RL/CD23 by IL-4.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Receptores Fc
/
Linfocinas
/
Sustancias de Crecimiento
Límite:
Humans
Idioma:
En
Revista:
J Exp Med
Año:
1987
Tipo del documento:
Article