Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086.
Nat Prod Res
; 33(3): 414-419, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-29600717
ABSTRACT
A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Penicillium
/
Polienos
/
Dicetopiperazinas
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2019
Tipo del documento:
Article