Targeting Myeloid-derived Suppressor Cells and Programmed Death Ligand 1 Confers Therapeutic Advantage of Ablative Hypofractionated Radiation Therapy Compared With Conventional Fractionated Radiation Therapy.

Lan, Jie; Li, Rui; Yin, Li-Mei; Deng, Lei; Gui, Jun; Chen, Bao-Qing; Zhou, Lin; Meng, Mao-Bin; Huang, Qiao-Rong; Mo, Xian-Ming; Wei, Yu-Quan; Lu, Bo; Dicker, Adam; Xue, Jian-Xin; Lu, You

Lan, Jie; Li, Rui; Yin, Li-Mei; Deng, Lei; Gui, Jun; Chen, Bao-Qing; Zhou, Lin; Meng, Mao-Bin; Huang, Qiao-Rong; Mo, Xian-Ming; Wei, Yu-Quan; Lu, Bo; Dicker, Adam; Xue, Jian-Xin; Lu, You.

Afiliación

Lan J; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Li R; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yin LM; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Deng L; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Gui J; Department of Biomedical Sciences, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Chen BQ; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Zhou L; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Meng MB; Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Huang QR; Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China.
Mo XM; Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China.
Wei YQ; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Lu B; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Dicker A; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Xue JX; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address: killercell@163.com.
Lu Y; Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address: radyoulu@hotmail.com.

Int J Radiat Oncol Biol Phys ; 101(1): 74-87, 2018 05 01.

Article en En | MEDLINE | ID: mdl-29619980

Asunto(s)

Antígeno B7-H1/uso terapéutico; Carcinoma Pulmonar de Lewis/radioterapia; Inmunoterapia Adoptiva/métodos; Melanoma Experimental/radioterapia; Células Supresoras de Origen Mieloide/efectos de la radiación; Receptor de Muerte Celular Programada 1/metabolismo; Hipofraccionamiento de la Dosis de Radiación; Animales; Linfocitos T CD8-positivos/efectos de la radiación; Carcinoma Pulmonar de Lewis/inmunología; Carcinoma Pulmonar de Lewis/metabolismo; Carcinoma Pulmonar de Lewis/patología; Terapia Combinada/métodos; Fraccionamiento de la Dosis de Radiación; Citometría de Flujo; Inmunocompetencia; Huésped Inmunocomprometido; Linfocitos Infiltrantes de Tumor/efectos de la radiación; Melanoma Experimental/inmunología; Melanoma Experimental/metabolismo; Melanoma Experimental/patología; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Ratones Desnudos; Células Supresoras de Origen Mieloide/citología; Receptor de Muerte Celular Programada 1/antagonistas & inhibidores; Receptor de Muerte Celular Programada 1/inmunología; Distribución Aleatoria; Receptores de Factores de Crecimiento Endotelial Vascular/antagonistas & inhibidores; Receptores de Factores de Crecimiento Endotelial Vascular/metabolismo; Receptores de Factores de Crecimiento Endotelial Vascular/efectos de la radiación; Efectividad Biológica Relativa; Carga Tumoral/efectos de la radiación; Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores; Factor A de Crecimiento Endotelial Vascular/metabolismo; Factor A de Crecimiento Endotelial Vascular/efectos de la radiación

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Melanoma Experimental / Inmunoterapia Adoptiva / Carcinoma Pulmonar de Lewis / Antígeno B7-H1 / Receptor de Muerte Celular Programada 1 / Hipofraccionamiento de la Dosis de Radiación / Células Supresoras de Origen Mieloide Límite: Animals Idioma: En Revista: Int J Radiat Oncol Biol Phys Año: 2018 Tipo del documento: Article País de afiliación: China

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