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Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-ß plaques: A potential role in shaping plaque pathology?
Unger, Michael S; Marschallinger, Julia; Kaindl, Julia; Klein, Barbara; Johnson, Mary; Khundakar, Ahmad A; Roßner, Steffen; Heneka, Michael T; Couillard-Despres, Sebastien; Rockenstein, Edward; Masliah, Eliezer; Attems, Johannes; Aigner, Ludwig.
Afiliación
  • Unger MS; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
  • Marschallinger J; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Department of Neurology and Neurological Sciences, Stanford University School of M
  • Kaindl J; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
  • Klein B; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria.
  • Johnson M; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
  • Khundakar AA; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
  • Roßner S; Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.
  • Heneka MT; University Hospital Bonn, Clinic and Polyclinic for Neurology, Clinical Neuroscience, Bonn, Germany.
  • Couillard-Despres S; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria.
  • Rockenstein E; Department of Neuroscience, School of Medicine, University of California San Diego, San Diego, CA, USA.
  • Masliah E; Department of Neuroscience, School of Medicine, University of California San Diego, San Diego, CA, USA.
  • Attems J; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
  • Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria. Electronic address: ludwig.aigner@pmu.ac.at.
Alzheimers Dement ; 14(8): 1022-1037, 2018 08.
Article en En | MEDLINE | ID: mdl-29630865
INTRODUCTION: One characteristic of Alzheimer's disease is the formation of amyloid-ß plaques, which are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and infiltrating immune cells. METHODS: Here, we describe nonneurogenic doublecortin (DCX) positive cells, DCX being generally used as a marker for young immature neurons, at sites of amyloid-ß plaques in various transgenic amyloid mouse models and in human brains with plaque pathology. RESULTS: The plaque-associated DCX+ cells were not of neurogenic identity, instead most of them showed coexpression with markers for microglia (ionized calcium-binding adapter molecule 1) and for phagocytosis (CD68 and TREM2). Another subpopulation of plaque-associated DCX+ cells was negative for ionized calcium-binding adapter molecule 1 but was highly positive for the pan-leukocyte marker CD45. These hematopoietic cells were identified as CD3-and CD8-positive and CD4-negative T-cells. DISCUSSION: Peculiarly, the DCX+/ionized calcium-binding adapter molecule 1+ microglia and DCX+/CD8+ T-cells were closely attached, suggesting that these two cell types are tightly interacting and that this interaction might shape plaque pathology.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Linfocitos T CD8-positivos / Placa Amiloide / Enfermedad de Alzheimer / Proteínas Asociadas a Microtúbulos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Alzheimers Dement Año: 2018 Tipo del documento: Article País de afiliación: Austria

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microglía / Linfocitos T CD8-positivos / Placa Amiloide / Enfermedad de Alzheimer / Proteínas Asociadas a Microtúbulos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Alzheimers Dement Año: 2018 Tipo del documento: Article País de afiliación: Austria