Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.
Nat Commun
; 9(1): 1371, 2018 04 10.
Article
en En
| MEDLINE
| ID: mdl-29636452
ABSTRACT
HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via downmodulation of CD3, into a non-pathogenic SIVagm strain and test their impact on viral replication and pathogenicity in African green monkeys. Despite sustained high-level viremia over more than 4 years, moderately increased immune activation and transcriptional signatures of inflammation, the HIV-1-like SIVagm does not cause immunodeficiency or any other disease. These data indicate that species-specific host factors rather than intrinsic viral virulence factors determine the pathogenicity of primate lentiviruses.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
VIH-1
/
Virus de la Inmunodeficiencia de los Simios
/
Lentivirus de los Primates
/
Productos del Gen nef del Virus de la Inmunodeficiencia Humana
/
Proteínas del Virus de la Inmunodeficiencia Humana
/
Proteínas Reguladoras y Accesorias Virales
/
Especificidad del Huésped
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania