Total saponins of Albiziae Cortex show anti-hepatoma carcinoma effects by inducing S phase arrest and mitochondrial apoptosis pathway activation.

Qian, Yi; Han, Qing-Hua; Wang, Li-Chao; Guo, Qiang; Wang, Xu-Da; Tu, Peng-Fei; Zeng, Ke-Wu; Liang, Hong

Qian, Yi; Han, Qing-Hua; Wang, Li-Chao; Guo, Qiang; Wang, Xu-Da; Tu, Peng-Fei; Zeng, Ke-Wu; Liang, Hong.

Afiliación

Qian Y; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Han QH; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Wang LC; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, C
Guo Q; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Wang XD; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Tu PF; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
Zeng KW; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: ZKW@bjmu.edu.cn.
Liang H; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: lianghong@bjmu.edu.cn.

J Ethnopharmacol ; 221: 20-29, 2018 Jul 15.

Article en En | MEDLINE | ID: mdl-29655853

Asunto(s)

Albizzia; Antineoplásicos Fitogénicos/uso terapéutico; Neoplasias Hepáticas Experimentales/tratamiento farmacológico; Saponinas/uso terapéutico; Animales; Antineoplásicos Fitogénicos/farmacología; Apoptosis/efectos de los fármacos; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Ciclina A/metabolismo; Ciclina E/metabolismo; Quinasa 2 Dependiente de la Ciclina/metabolismo; Humanos; Neoplasias Hepáticas Experimentales/metabolismo; Neoplasias Hepáticas Experimentales/patología; Masculino; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Ratones Endogámicos ICR; Mitocondrias/efectos de los fármacos; Mitocondrias/fisiología; Fitoterapia; Extractos Vegetales/química; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Fase S/efectos de los fármacos; Saponinas/farmacología; Carga Tumoral

Palabras clave

Anti-hepatoma carcinoma; Apoptosis; Cell cycle arrest; Mitochondrial pathway; Total saponins of Albiziae Cortex

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Saponinas / Albizzia / Neoplasias Hepáticas Experimentales / Antineoplásicos Fitogénicos Límite: Animals / Humans / Male Idioma: En Revista: J Ethnopharmacol Año: 2018 Tipo del documento: Article País de afiliación: China

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