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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
Pike, Kurt G; Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Chen, Yingxue; Colclough, Nicola; Davies, Nichola L; de-Almeida, Camila; Degorce, Sebastien L; Didelot, Myriam; Dishington, Allan; Ducray, Richard; Durant, Stephen T; Hassall, Lorraine A; Holmes, Jane; Hughes, Gareth D; MacFaul, Philip A; Mulholland, Keith R; McGuire, Thomas M; Ouvry, Gilles; Pass, Martin; Robb, Graeme; Stratton, Natalie; Wang, Zhenhua; Wilson, Joanne; Zhai, Baochang; Zhao, Kang; Al-Huniti, Nidal.
Afiliación
  • Pike KG; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Barlaam B; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Cadogan E; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Campbell A; Pharmaceutical Sciences , AstraZeneca , Silk Road Business Park, Macclesfield SK10 2NA , U.K.
  • Chen Y; Oncology, IMED Biotech Unit , AstraZeneca , 35 Gatehouse Drive , Waltham , Massachusetts 02451 , United States.
  • Colclough N; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Davies NL; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • de-Almeida C; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Degorce SL; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Didelot M; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France.
  • Dishington A; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France.
  • Ducray R; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K.
  • Durant ST; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France.
  • Hassall LA; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Holmes J; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K.
  • Hughes GD; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K.
  • MacFaul PA; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Mulholland KR; Oncology, IMED Biotech Unit , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K.
  • McGuire TM; Chemical Development , AstraZeneca , Silk Road Business Park , Macclesfield SK10 2NA , U.K.
  • Ouvry G; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Pass M; Oncology, IMED Biotech Unit , AstraZeneca, Centre de Recherches, Z. I. la Pompelle , BP 1050, 51689 Reims Cedex 2 , France.
  • Robb G; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Stratton N; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Wang Z; Discovery Sciences , AstraZeneca , Alderley Park , Macclesfield , Cheshire SK10 4TG , U.K.
  • Wilson J; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China.
  • Zhai B; Oncology, IMED Biotech Unit , AstraZeneca , Building 310, Cambridge Science Park, 319 Milton Road , Cambridge CB4 0WG , U.K.
  • Zhao K; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China.
  • Al-Huniti N; Pharmaron Beijing Co., Ltd. , 6 Taihe Road BDA , Beijing 100176 , P.R. China.
J Med Chem ; 61(9): 3823-3841, 2018 05 10.
Article en En | MEDLINE | ID: mdl-29683659
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Quinolinas / Diseño de Fármacos / Quinolonas / Proteínas de la Ataxia Telangiectasia Mutada Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Quinolinas / Diseño de Fármacos / Quinolonas / Proteínas de la Ataxia Telangiectasia Mutada Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido