Cortical spreading depression as a site of origin for migraine: Role of CGRP.
Cephalalgia
; 39(3): 428-434, 2019 03.
Article
en En
| MEDLINE
| ID: mdl-29695168
ABSTRACT
PREMISE Migraine is a complex neurologic disorder that leads to significant disability, yet remains poorly understood. PROBLEM:
One potential triggering mechanism in migraine with aura is cortical spreading depression, which can activate the trigeminal nociceptive system both peripherally and centrally in animal models. A primary neuropeptide of the trigeminal system is calcitonin gene-related peptide, which is a potent vasodilatory peptide and is currently a major therapeutic target for migraine treatment. Despite the importance of both cortical spreading depression and calcitonin gene-related peptide in migraine, the relationship between these two players has been relatively unexplored. However, recent data suggest several potential vascular and neural connections between calcitonin gene-related peptide and cortical spreading depression.CONCLUSION:
This review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Depresión de Propagación Cortical
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Vasodilatación
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Péptido Relacionado con Gen de Calcitonina
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Trastornos Migrañosos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cephalalgia
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos