Optical Coherence Tomography Angiography to Quantify Choroidal Neovascularization in Response to Aflibercept.
Ophthalmologica
; 240(2): 90-98, 2018.
Article
en En
| MEDLINE
| ID: mdl-29739007
ABSTRACT
PURPOSE:
To investigate the microvascular changes in choroidal neovascularization (CNV) using optical coherence tomography angiography (OCTA) during anti-vascular endothelial growth factor (VEGF) therapies.METHODS:
We retrospectively collected data on consecutive treatment-naïve eyes with typical age-related macular degeneration that initially received 3 aflibercept injections. OCTA was performed at baseline and at 1, 2, and 4 months of follow-up. The CNV images were analyzed using open-source software to assess vessel area and junction density.RESULTS:
Fifteen eyes of 15 patients were included. The mean vessel area at baseline was 0.50 ± 0.33 mm2; at 1, 2, and 4 months, the ratios of change in vessel area from baseline were 66.6 ± 38.8%, 80.5 ± 25.5%, and 94.0 ± 29.3%, respectively. The vessel area was significantly reduced at 1 month from that at baseline (p = 0.0015) but significantly increased at 4 months from that at 1 month (p = 0.011). The mean junction density was also significantly reduced from 4.70 ± 1.30/mm at baseline to 3.82 ± 1.06/mm at 1 month (p = 0.00084). However, junction density did not continue to decrease at 2 and 4 months.CONCLUSION:
OCTA quantification revealed that CNV rebounded after repeat aflibercept injections despite shrinking in response to the first injection.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes de Fusión
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Angiografía con Fluoresceína
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Coroides
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Neovascularización Coroidal
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Receptores de Factores de Crecimiento Endotelial Vascular
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Tomografía de Coherencia Óptica
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ophthalmologica
Año:
2018
Tipo del documento:
Article