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Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Iwai, Kenichi; Yaguchi, Masahiro; Nishimura, Kazuho; Yamamoto, Yukiko; Tamura, Toshiya; Nakata, Daisuke; Dairiki, Ryo; Kawakita, Yoichi; Mizojiri, Ryo; Ito, Yoshiteru; Asano, Moriteru; Maezaki, Hironobu; Nakayama, Yusuke; Kaishima, Misato; Hayashi, Kozo; Teratani, Mika; Miyakawa, Shuichi; Iwatani, Misa; Miyamoto, Maki; Klein, Michael G; Lane, Wes; Snell, Gyorgy; Tjhen, Richard; He, Xingyue; Pulukuri, Sai; Nomura, Toshiyuki.
Afiliación
  • Iwai K; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Yaguchi M; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Nishimura K; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Yamamoto Y; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Tamura T; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Nakata D; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Dairiki R; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Kawakita Y; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Mizojiri R; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Ito Y; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Asano M; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Maezaki H; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Nakayama Y; Integrated Technology Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Kaishima M; Integrated Technology Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Hayashi K; Integrated Technology Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Teratani M; Integrated Technology Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Miyakawa S; Biomolecular Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Iwatani M; Biomolecular Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Miyamoto M; Drug Metabolism & Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan.
  • Klein MG; Department of Structural Biology, Takeda California Inc., San Diego, CA, USA.
  • Lane W; Department of Structural Biology, Takeda California Inc., San Diego, CA, USA.
  • Snell G; Department of Structural Biology, Takeda California Inc., San Diego, CA, USA.
  • Tjhen R; Department of Structural Biology, Takeda California Inc., San Diego, CA, USA.
  • He X; Oncology Drug Discovery Unit, Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
  • Pulukuri S; Oncology Drug Discovery Unit, Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
  • Nomura T; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Limited, Fujisawa, Japan toshiyuki.nomura@takeda.com.
EMBO Mol Med ; 10(6)2018 06.
Article en En | MEDLINE | ID: mdl-29769258
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Quinolinas / Proteínas Tirosina Quinasas / Empalme del ARN / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Diaminas Límite: Animals / Humans Idioma: En Revista: EMBO Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Quinolinas / Proteínas Tirosina Quinasas / Empalme del ARN / Proteínas Serina-Treonina Quinasas / Inhibidores de Proteínas Quinasas / Diaminas Límite: Animals / Humans Idioma: En Revista: EMBO Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Japón