Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial.
J Intensive Care Med
; 35(7): 687-693, 2020 Jul.
Article
en En
| MEDLINE
| ID: mdl-29788815
ABSTRACT
OBJECTIVES:
There is currently no evidence that whether magnesium supplementation would improve stress-induced hyperglycemia (SIH) in critically ill patients. In this study, effects of magnesium loading dose on insulin resistance (IR) indices were evaluated in critically ill patients without diabetes having SIH.METHODS:
Seventy critically ill patients with SIH were assigned to receive a loading dose of magnesium (7.5 g of magnesium sulfate in 500 mL normal saline as intravenous infusion over an 8-hour period) or placebo. Changes in baseline of serum and intracellular magnesium and serum adiponectin (AD) levels, homeostasis model assessment of IR (HOMA-IR), and HOMA-AD ratio were assessed in this study.RESULTS:
Serum and intracellular magnesium levels increased significantly in patients in the magnesium group (P < .001). At day 3, there were significant differences between the magnesium group and the placebo group in the mean changes from baseline in the HOMA (between-group difference -0.11; 95% confidence interval [CI] -0.19 to -0.01; P = .02), the AD (between-group difference 0.94; 95% CI 0.41-1.48; P = .04), and the HOMA-AD ratio (between-group difference -0.03; 95% CI -0.04 to -0.01; P < .001).CONCLUSION:
In the present study, a single-loading dose of intravenous magnesium improved IR indices in critically ill patients with SIH.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Adiponectina
/
Hiperglucemia
/
Magnesio
/
Sulfato de Magnesio
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Intensive Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán