Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity.
Annu Rev Nutr
; 38: 401-429, 2018 08 21.
Article
en En
| MEDLINE
| ID: mdl-29799766
ABSTRACT
Exposure to inorganic arsenic (InAs) via drinking water and/or food is a considerable worldwide problem. Methylation of InAs generates monomethyl (MMAsIII+V)- and dimethyl (DMAsIII+V)-arsenical species in a process that facilitates urinary As elimination; however, MMAs is considerably more toxic than either InAs or DMAs. Emerging evidence suggests that incomplete methylation of As to DMAs, resulting in increased MMAs, is associated with increased risk for a host of As-related health outcomes. The biochemical pathway that provides methyl groups for As methylation, one-carbon metabolism (OCM), is influenced by folate and other micronutrients, including choline and betaine. Individuals and species differ widely in their ability to methylate As. A growing body of research, including cell-culture, animal-model, and epidemiological studies, has demonstrated the role of OCM-related micronutrients in As methylation. This review examines the evidence that nutritional status and nutritional interventions can influence the metabolism and toxicity of As, with a primary focus on folate.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arsénico
/
Carbono
/
Fenómenos Fisiológicos de la Nutrición
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Nutr
Año:
2018
Tipo del documento:
Article