Non-syndromic cleft lip and/or cleft palate: Epidemiology and risk factors in Lubumbashi (DR Congo), a case-control study.
J Craniomaxillofac Surg
; 46(7): 1051-1058, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29802056
ABSTRACT
PURPOSE:
To determine the incidence and risk factors of occurrence of non-syndromic cleft lip and/or cleft palate (NSCLP) in Lubumbashi.METHOD:
A case-control study was conducted in the health district of Lubumbashi from February 2012 to December 2015. An exhaustive sampling, collecting all newborns with cleft lip and/or cleft palate (CL ± P) in maternity wards was conducted. From a total of 172 cases, 162 non-syndromic cases were recruited. For each case, one clinically normal newborn control was selected.RESULTS:
NSCLP had an incidence of 1/1258 live births (0.8/1000). We found significant associations with a family history of cleft lip and palate (CLP) (x2family history = 11.5, p = 0.0007), maternal alcohol intake (OR = 19.3, 95% CI 1.9-197.1), paternal alcohol during the periconceptional period and the first trimester of pregnancy (OR = 18.7, 95% CI 3.9-89.2), maternal educational level lower than high school (OR = 9.5, 95% CI 2.0-44.7), clay (Pemba) consumption during pregnancy (OR = 38.3, 95% CI 9.3-157.0), the use of insecticides in the evening (OR = 130.3, 95% CI 13.2-1286.9), indoor cooking with charcoal (Makala) (OR = 6.5, 95% CI 1.22-34.5), and regular consumption of Kapolowe fish, supposedly contaminated with heavy metals (OR = 29.5, 95% CI 7.4-116.7).CONCLUSION:
Several environmental risk factors highly prevalent in Central Africa for facial clefting were found.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Labio Leporino
/
Fisura del Paladar
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Female
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Humans
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Male
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Newborn
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Pregnancy
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Craniomaxillofac Surg
Asunto de la revista:
ODONTOLOGIA
Año:
2018
Tipo del documento:
Article