Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis.
Nat Prod Rep
; 35(8): 735-756, 2018 08 15.
Article
en En
| MEDLINE
| ID: mdl-29808887
ABSTRACT
Covering up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of ß-lactam ring containing natural products. IPNS catalyses formation of the bicyclic penicillin nucleus from a tripeptide. 2OG oxygenases catalyse reactions that diversify the chemistry of ß-lactams formed by both IPNS and non-oxidative enzymes. Reactions catalysed by the 2OG oxygenases of ß-lactam biosynthesis not only involve their typical hydroxylation reactions, but also desaturation, epimerisation, rearrangement, and ring-forming reactions. Some of the enzymes involved in ß-lactam biosynthesis exhibit remarkable substrate and product selectivities. We review the roles of 2OG oxygenases and IPNS in ß-lactam biosynthesis, highlighting opportunities for application of knowledge of their roles, structures, and mechanisms.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Beta-Lactamas
/
Oxigenasas de Función Mixta
Idioma:
En
Revista:
Nat Prod Rep
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article