Non-coding RNAs in virology: an RNA genomics approach.
Biotechnol Genet Eng Rev
; 34(1): 90-106, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29865927
ABSTRACT
Advances in sequencing technologies and bioinformatic analysis techniques have greatly improved our understanding of various classes of RNAs and their functions. Despite not coding for proteins, non-coding RNAs (ncRNAs) are emerging as essential biomolecules fundamental for cellular functions and cell survival. Interestingly, ncRNAs produced by viruses not only control the expression of viral genes, but also influence host cell regulation and circumvent host innate immune response. Correspondingly, ncRNAs produced by the host genome can play a key role in host-virus interactions. In this article, we will first discuss a number of types of viral and mammalian ncRNAs associated with viral infections. Subsequently, we also describe the new possibilities and opportunities that RNA genomics and next-generation sequencing technologies provide for studying ncRNAs in virology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus
/
Virosis
/
ARN no Traducido
/
Genómica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biotechnol Genet Eng Rev
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá