Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer.
Ultraschall Med
; 40(3): 340-348, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-29874683
PURPOSE: The aim of this study was to investigate contrast-enhanced ultrasound (CEUS) parameters acquired by software during magnetic resonance imaging (MRI) US fusion-guided biopsy for prostate cancer (PCa) detection and discrimination. MATERIALS AND METHODS: From 2012 to 2015, 158 out of 165 men with suspicion for PCa and with at least 1 negative biopsy of the prostate were included and underwent a multi-parametric 3 Tesla MRI and an MRI/US fusion-guided biopsy, consecutively. CEUS was conducted during biopsy with intravenous bolus application of 2.4âmL of SonoVue® (Bracco, Milan, Italy). In the latter CEUS clips were investigated using quantitative perfusion analysis software (VueBox, Bracco). The area of strongest enhancement within the MRI pre-located region was investigated and all available parameters from the quantification tool box were collected and analyzed for PCa and its further differentiation was based on the histopathological results. RESULTS: The overall detection rate was 74 (47â%) PCa cases in 158 included patients. From these 74 PCa cases, 49 (66â%) were graded Gleason ≥â3â+â4â=â7 (ISUP ≥â2) PCa. The best results for cancer detection over all quantitative perfusion parameters were rise time (pâ=â0.026) and time to peak (pâ=â0.037). Within the subgroup analysis (> vs ≤â3â+â4â=â7a (ISUP 2)), peak enhancement (pâ=â0.012), wash-in rate (pâ=â0.011), wash-out rate (pâ=â0.007) and wash-in perfusion index (pâ=â0.014) also showed statistical significance. CONCLUSION: The quantification of CEUS parameters was able to discriminate PCa aggressiveness during MRI/US fusion-guided prostate biopsy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Ultrasonografía
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Ultraschall Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania