A role for glycosylation of the alpha subunit in transduction of biological signal in glycoprotein hormones.
Science
; 229(4708): 65-7, 1985 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-2990039
ABSTRACT
The biological properties of recombinants of glycoprotein hormones in which the alpha and beta subunits were differentially deglycosylated have been investigated. Specific deglycosylation of the alpha subunit generated a recombinant that had more receptor-binding activity but did not produce hormone response in the target cells. The deglycosylated alpha + beta recombinant was also an antagonist of the action of the native hormone. Thus, the carbohydrates in the alpha subunit play a dominant role in the transduction of the hormone signal into the cell.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona Luteinizante
/
Glicoproteínas
/
Receptores de Superficie Celular
/
Hormona Folículo Estimulante
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1985
Tipo del documento:
Article