Harnessing Tumor Evolution to Circumvent Resistance.
Trends Genet
; 34(8): 639-651, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29903534
ABSTRACT
High-throughput sequencing can be used to measure changes in tumor composition across space and time. Specifically, comparisons of pre- and post-treatment samples can reveal the underlying clonal dynamics and resistance mechanisms. Here, we discuss evidence for distinct modes of tumor evolution and their implications for therapeutic strategies. In addition, we consider the utility of spatial tissue sampling schemes, single-cell analysis, and circulating tumor DNA to track tumor evolution and the emergence of resistance, as well as approaches that seek to forestall resistance by targeting tumor evolution. Ultimately, characterization of the (epi)genomic, transcriptomic, and phenotypic changes that occur during tumor progression coupled with computational and mathematical modeling of tumor evolutionary dynamics may inform personalized treatment strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Modelos Biológicos
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2018
Tipo del documento:
Article