Multidrug efflux pumps: structure, function and regulation.
Nat Rev Microbiol
; 16(9): 523-539, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-30002505
ABSTRACT
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Resistencia a Múltiples Medicamentos
/
Transportadoras de Casetes de Unión a ATP
/
Farmacorresistencia Bacteriana
Idioma:
En
Revista:
Nat Rev Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Reino Unido