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Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.
Al-Awadhi, Fatma H; Gao, Bowen; Rezaei, Mohammad A; Kwan, Jason C; Li, Chenglong; Ye, Tao; Paul, Valerie J; Luesch, Hendrik.
Afiliación
  • Al-Awadhi FH; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
  • Gao B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Kuwait University , P.O. Box 24923, Safat 13110 , Kuwait.
  • Rezaei MA; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District , Shenzhen , 518055 , China.
  • Kwan JC; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
  • Li C; Department of Chemistry , University of Florida , Gainesville , Florida 32611 , United States.
  • Ye T; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
  • Paul VJ; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
  • Luesch H; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District , Shenzhen , 518055 , China.
J Med Chem ; 61(14): 6364-6378, 2018 Jul 26.
Article en En | MEDLINE | ID: mdl-30015488
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Calicreínas / Diseño de Fármacos / Cianobacterias / Receptores Acoplados a Proteínas G / Amidas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Calicreínas / Diseño de Fármacos / Cianobacterias / Receptores Acoplados a Proteínas G / Amidas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos