Contact-Dependent Growth Inhibition Proteins in Acinetobacter baylyi ADP1.
Curr Microbiol
; 75(11): 1434-1440, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-30019131
ABSTRACT
Bacterial contact-dependent growth inhibition (CDI) systems are two-partner secretion systems in which toxic CdiA proteins are exported on the outer membrane by cognate transporter CdiB proteins. Upon binding to specific receptors, the C-terminal toxic (CT) domain, detached from CdiA, is delivered to neighbouring cells. Contacts inhibit the growth of not-self-bacteria, lacking immunity proteins co-expressed with CdiA, but promote cooperative behaviours in "self" bacteria, favouring the formation of biofilm structures. The Acinetobacter baylyi ADP1 strain features two CdiA, which differ significantly in size and have different CT domains. Homologous proteins sharing the same CT domains have been identified in A. baumannii. The growth inhibition property of the two A. baylyi CdiA proteins was supported by competition assays between wild-type cells and mutants lacking immunity genes. However, neither protein plays a role in biofilm formation or adherence to epithelial cells, as proved by assays carried out with knockout mutants. Inhibitory and stimulatory properties may be similarly uncoupled in A. baumannii proteins.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Acinetobacter
/
Inhibición de Contacto
/
Proteínas de la Membrana
Límite:
Humans
Idioma:
En
Revista:
Curr Microbiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia