Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
J Leukoc Biol
; 104(4): 729-735, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30020539
Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with their replication complex. This association results in a restriction of the respective pathogen, yet the exact molecular mechanisms of the antimicrobial functions of GBPs are still unclear. Recent work has linked the GBPs with the activation of inflammasomes, multi-protein complexes that assemble upon recognition of pathogen- or host-derived signals and that drive the release of cytokines and host cell death. Here, we will focus on the most recent findings that have started to unravel the manifold restriction mechanism controlled by GBPs in mouse and human cells, and that shed light on the molecular cues that control GBP recruitment to bacterial membranes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al GTP
/
Inmunidad Innata
/
Infecciones
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Leukoc Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Suiza