Your browser doesn't support javascript.
loading
Association of In Utero Persistent Organic Pollutant Exposure With Placental Thyroid Hormones.
Li, Zhong-Min; Hernandez-Moreno, David; Main, Katharina Maria; Skakkebæk, Niels Erik; Kiviranta, Hannu; Toppari, Jorma; Feldt-Rasmussen, Ulla; Shen, Heqing; Schramm, Karl-Werner; De Angelis, Meri.
Afiliación
  • Li ZM; Helmholtz Zentrum München-German Research Center for Environmental Health, Molecular EXposomics, Neuherberg, Germany.
  • Hernandez-Moreno D; School of Life Sciences Weihenstephan (Nutrition), Technische Universität München, Freising, Germany.
  • Main KM; Helmholtz Zentrum München-German Research Center for Environmental Health, Molecular EXposomics, Neuherberg, Germany.
  • Skakkebæk NE; Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kiviranta H; Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Toppari J; National Institute for Health and Welfare, Department of Health Security, Kuopio, Finland.
  • Feldt-Rasmussen U; Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Shen H; Institute of Biomedicine, University of Turku, Turku, Finland.
  • Schramm KW; Department of Pediatrics, Turku University Hospital, Turku, Finland.
  • De Angelis M; Department of Medical Endocrinology PE, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Endocrinology ; 159(10): 3473-3481, 2018 10 01.
Article en En | MEDLINE | ID: mdl-30059991
In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The associations between placental levels of various POPs and thyroid hormones (THs) were investigated. In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (n = 28) and without (n = 30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), T4, T3, and rT3 were measured. The associations between placental THs and various POPs were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation between THs and the odds of cryptorchidism was found. Several POPs were significantly associated with THs: (1) T4 was inversely associated with BDEs 99, 100, ΣPBDE, and 2378-TeCDD, and positively associated with 1234678-HpCDF; (2) T3 was positively associated with 2378-TeCDF and 12378-PeCDF; and (3) rT3 was positively associated with PCB 81, 12378-PeCDF, and 234678-HxCDF, and inversely associated with tributyltin, ΣOTC, and methoxychlor. These results revealed that POP exposures were associated with TH levels in placenta, which may be a possible mechanism for the impacts of POP exposures on children's growth and development. This study provides new insight into the complexity of thyroid-disrupting properties of POPs. More research is needed to elucidate the biological consequences of POP exposures.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Hormonas Tiroideas / Exposición Materna / Contaminantes Ambientales Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male / Pregnancy Idioma: En Revista: Endocrinology Año: 2018 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Placenta / Hormonas Tiroideas / Exposición Materna / Contaminantes Ambientales Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Child / Female / Humans / Male / Pregnancy Idioma: En Revista: Endocrinology Año: 2018 Tipo del documento: Article País de afiliación: Alemania