Volumetric breast density and risk of advanced cancers after a negative screening episode: a cohort study.
Breast Cancer Res
; 20(1): 95, 2018 08 09.
Article
en En
| MEDLINE
| ID: mdl-30092817
ABSTRACT
BACKGROUND:
We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode.METHODS:
A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories.RESULTS:
BC incidence gradually increased with the increas in BD 3.7, 5.1, 5.4 and 9.1 in the VDG categories 1-4, respectively (p trend < 0.001). The risk of advanced cancers after a negative screening episode was 1.0, 1.3, 1.1, and 4.2 (p trend = 0.003). The highest BD category, compared with the other three together, has double the invasive BC risk (RR = 2.0; 95% CI 1.5-2.8) and almost fourfold risk of advanced cancer (RR = 3.8; 95% CI 1.8-8.0).CONCLUSION:
BD has a strong impact on the risk of advanced cancers after a negative screening episode, the best early surrogate of BC mortality. Therefore, our results suggest that screening effectiveness is quite different among BD categories.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Evaluación de Procesos y Resultados en Atención de Salud
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Neoplasias de la Mama
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Mamografía
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Detección Precoz del Cáncer
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Densidad de la Mama
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
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Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Breast Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Italia