Effect of Mannitol Infusion on Optic Nerve Injury After Acute Traumatic Subarachnoid Hemorrhage and Brain Injury.
J Craniofac Surg
; 29(7): 1772-1775, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30106807
ABSTRACT
The primary aim of this paper is to investigate the neuroprotective and antiinflammatory effects of mannitol on optic nerve injury after acute traumatic subarachnoid hemorrhage and brain injury in rat models. Traumatic brain injury (TBI) and traumatic subarachnoid hemorrhage (tSAH) were produced by a custom-made weight-drop impact acceleration device. Thirty male Wistar rats were divided into 3 groups. Group I (nâ=â10) was the sham group, group II (nâ=â10) received TBI, and group III (nâ=â10) received TBI + mannitol (1âmg/kg intravenously). Optic nerve tissue glutathione peroxidase (GPx) and interleukin 1 beta (IL-1ß) levels were measured 4âhours after the trauma. The authors used Kruskal-Wallis variance analysis and Mann-Whitney U tests for statistical analysis. Optic nerve tissue GPx levels were significantly higher in group III than in groups I and II (Pâ<â0.05). Optic nerve tissue IL-1ß levels were significantly lower in group III than in group II (Pâ<â0.05) and higher than in group I (Pâ<â0.05).Mannitol increased the antioxidant GPx levels and decreased the IL-1ß levels, which can protect the optic nerve from secondary injury after severe acute trauma. Mannitol plays an important role in the treatment of acute severe indirect optic nerve injury after TBI and tSAH.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
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Traumatismos del Nervio Óptico
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Interleucina-1beta
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Glutatión Peroxidasa
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Manitol
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Craniofac Surg
Asunto de la revista:
ODONTOLOGIA
Año:
2018
Tipo del documento:
Article