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A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.
Stylianou, Nataly; Lehman, Melanie L; Wang, Chenwei; Fard, Atefeh Taherian; Rockstroh, Anja; Fazli, Ladan; Jovanovic, Lidija; Ward, Micheal; Sadowski, Martin C; Kashyap, Abhishek S; Buttyan, Ralph; Gleave, Martin E; Westbrook, Thomas F; Williams, Elizabeth D; Gunter, Jennifer H; Nelson, Colleen C; Hollier, Brett G.
Afiliación
  • Stylianou N; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Lehman ML; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Wang C; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
  • Fard AT; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Rockstroh A; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Fazli L; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Jovanovic L; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
  • Ward M; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Sadowski MC; Glycation and Diabetic Complications Group, Mater Research Institute, Translational Research Institute, School of Medicine, University of Queensland, Brisbane, QLD, Australia.
  • Kashyap AS; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Buttyan R; Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
  • Gleave ME; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
  • Westbrook TF; Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.
  • Williams ED; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Gunter JH; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Nelson CC; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
  • Hollier BG; Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.
Oncogene ; 38(7): 913-934, 2019 02.
Article en En | MEDLINE | ID: mdl-30194451
The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial-mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcriptional investigations using reversible models of EMT, revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC). From this enrichment, a metastasis-derived gene signature was identified that predicted more rapid cancer relapse and reduced survival across multiple human carcinoma types. Additionally, the transcriptional profile of MErT is not a simple mirror image of EMT as tumour cells retain a transcriptional "memory" following a reversible EMT. This memory was also enriched in mCRPC samples. Cumulatively, our studies reveal the transcriptional profile of epithelial-mesenchymal plasticity and highlight the unique transcriptional properties of MErT. Furthermore, our findings provide evidence to support the association of epithelial plasticity with poor clinical outcomes in multiple human carcinoma types.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transición Epitelial-Mesenquimal / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transición Epitelial-Mesenquimal / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Australia