The effects of cardiovascular risk factor combined anti-platelet therapy and the risk of cerebrovascular events in patients with T2DM in an urban community over 96-months follow-up: The Beijing communities diabetes study 19.
Diabetes Res Clin Pract
; 144: 236-244, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30218743
ABSTRACT
OBJECTIVE:
We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events.METHODS:
A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS). According to the total metabolic score (TMS), the patients were divided into four equal groups Group 1 (24â¯<â¯TMSâ¯<â¯40), Group 2 (40â¯<â¯TMSâ¯<â¯47), Group 3 (47â¯<â¯TMSâ¯<â¯55) and Group 4 (55â¯<â¯TMSâ¯<â¯87). After 96â¯months, patients were followed-up to assess the long-term effects of the multifactorial interventions.RESULTS:
During 96-months follow-up, a total of 91 cerebrovascular events occurred, including acute cerebral infarction, acute cerebral hemorrhage and transient ischemic attack (TIA). The incidence of cerebrovascular events was higher in the Group 4 than in the Group 1. In Cox multivariate analyses, there are significant differences in incidences of cerebral infarction events among the four groups during the 96-months follow-up. Cox proportional hazards analysis revealed that, HbA1c (pâ¯≤â¯0.001), systolic pressure (pâ¯≤â¯0.001), aspirin free treatment (Pâ¯=â¯0.0023) are independent predictor for cerebrovascular events in diabetic patients.CONCLUSIONS:
This study indicates that total metabolic score (TMS) influences the incidence of cerebrovascular events in diabetic patients. In addition to good control of blood glucose, blood pressure and lipid profiles, anti-platelet therapy is important for the prevention of cerebrovascular events in T2DM. TRIAL REGISTRATION ChiCTR-TRC-13003978, ChiCTR-OOC-15006090.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Agregación Plaquetaria
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Enfermedades Cardiovasculares
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Trastornos Cerebrovasculares
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Aspirina
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Diabetes Mellitus Tipo 2
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Diabetes Res Clin Pract
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China