Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia.
Proc Natl Acad Sci U S A
; 115(41): 10422-10427, 2018 10 09.
Article
en En
| MEDLINE
| ID: mdl-30249639
ABSTRACT
Louse-borne relapsing fever (LBRF) is known to have killed millions of people over the course of European history and remains a major cause of mortality in parts of the world. Its pathogen, Borrelia recurrentis, shares a common vector with global killers such as typhus and plague and is known for its involvement in devastating historical epidemics such as the Irish potato famine. Here, we describe a European and historical genome of Brecurrentis, recovered from a 15th century skeleton from Oslo. Our distinct European lineage has a discrete genomic makeup, displaying an ancestral oppA-1 gene and gene loss in antigenic variation sites. Our results illustrate the potential of ancient DNA research to elucidate dynamics of reductive evolution in a specialized human pathogen and to uncover aspects of human health usually invisible to the archaeological record.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fiebre Recurrente
/
Proteínas Bacterianas
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Borrelia
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Genoma Bacteriano
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Metagenómica
Límite:
Adult
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Animals
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Child
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Female
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Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2018
Tipo del documento:
Article