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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.
Schmitt, Kimberly; Curlin, James; Kumar, Dipu Mohan; Remling-Mulder, Leila; Feely, Stephanie; Stenglein, Mark; O'Connor, Shelby; Marx, Preston; Akkina, Ramesh.
Afiliación
  • Schmitt K; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
  • Curlin J; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
  • Kumar DM; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
  • Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
  • Feely S; Tulane National Primate Research Center, Covington, Louisiana.
  • Stenglein M; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
  • O'Connor S; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
  • Marx P; Tulane National Primate Research Center, Covington, Louisiana.
  • Akkina R; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
J Med Primatol ; 47(5): 298-301, 2018 10.
Article en En | MEDLINE | ID: mdl-30255956
ABSTRACT
How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: VIH-2 / Cercocebus atys / Modelos Animales de Enfermedad Límite: Animals / Humans Idioma: En Revista: J Med Primatol Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: VIH-2 / Cercocebus atys / Modelos Animales de Enfermedad Límite: Animals / Humans Idioma: En Revista: J Med Primatol Año: 2018 Tipo del documento: Article