SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.
J Med Primatol
; 47(5): 298-301, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30255956
ABSTRACT
How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
VIH-2
/
Cercocebus atys
/
Modelos Animales de Enfermedad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Primatol
Año:
2018
Tipo del documento:
Article