Elevation of serum oxLDL/ß2-GPI complexes was correlated with diabetic microvascular complications in Type 2 diabetes mellitus patients.
J Clin Lab Anal
; 33(2): e22676, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30259578
ABSTRACT
BACKGROUND:
High levels of oxLDL/ß2-GPI complexes might be a consequence of LDL atherogenic modification mediated by oxidative stress. We aimed to determine whether the levels of serum oxLDL/ß2-GPI complexes were correlated with diabetic microvascular complications in type 2 diabetes mellitus (T2DM) patients.METHODS:
Levels of oxLDL/ß2-GPI complexes, oxLDL, routine lipid/lipoprotein parameters were measured in 100 healthy controls, 128 T2DM patients without any microvascular complications, and 172 T2DM patients with microvascular complications. Spearman's correlation, multivariable linear regression logistic regression analysis, and receiver operating characteristic (ROC) curve were performed.RESULTS:
Levels of serum oxLDL/ß2-GPI complexes and oxLDL were significantly higher in T2DM patients with microvascular complications (oxLDL/ß2-GPI complexes 1.10 ± 0.18 U/mL; oxLDL 48.12 ± 7.24 mmol/L) than those in T2DM patients without microvascular complications (oxLDL/ß2-GPI complexes 0.98 ± 0.16 U/mL; oxLDL 41.45 ± 6.81 mmol/L) and controls (oxLDL/ß2-GPI complexes 0.79 ± 0.15 U/mL; oxLDL 27.85 ± 5.32 mmol/L). Variables that remained significantly associated with oxLDL/ß2-GPI complexes were oxLDL (ß = 0.568, P < 0.001), TC (ß = 0.312, P = 0.013) and microvascular complications (ß = 0.205, P = 0.027), which accounted for 58.3% of the variation of the level of oxLDL/ß2-GPI complexes in T2DM patients (R2 = 0.583). Logistic regression analysis demonstrated that elevation of oxLDL/ß2-GPI complexes (OR = 3.14, 95% CI 1.04-9.46, P = 0.042) and oxLDL levels (OR = 3.02, 95% CI 1.16-7.83, P = 0.023) were independently associated with occurrence of microvascular complications. Cutoff value of oxLDL/ß2-GPI for the presence of microvascular complications was 1.05 U/mL, and AUC area of ROC curve was 0.783 (95%CI 0.713-0.853), yielding a sensitivity of 86.8% and specificity of 64.9%.CONCLUSIONS:
Elevation of serum oxLDL/ß2-GPI complexes was associated with microvascular complications in T2DM patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
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Angiopatías Diabéticas
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Beta 2 Glicoproteína I
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Microvasos
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Lipoproteínas LDL
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Clin Lab Anal
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2019
Tipo del documento:
Article
País de afiliación:
China