Manipulation of the balance between Th2 and Th2/1 hybrid cells affects parasite nematode fitness in mice.
Eur J Immunol
; 48(12): 1958-1964, 2018 12.
Article
en En
| MEDLINE
| ID: mdl-30267404
ABSTRACT
T-helper type 2 (Th2) responses are central to the control of helminth infections, but sensitive to opposing cytokine signals favoring Th1 priming. We previously reported on GATA-3+ T-bet+ Th2/1 hybrid cell differentiation in helminth mono-infections, resulting in a substantial proportion of cells coproducing IFN-γ next to Th2 cytokines. Here, we demonstrate Th2/1 cells as the major source of parasite-specific IFN-γ production in acute and chronic infections with the enteric nematode Heligmosomoides polygyrus. Th2/1 cells differentiated from naive precursors and accumulated in spleen and intestine of infected mice, resulting in increased systemic and mucosal IFN-γ production. IFN-γ supplementation early during infection supported Th2/1 differentiation, associated with elevated parasite fecundity and the maintenance of high worm burdens in the chronic stage of infection, whereas mice lacking IFN-γ signals generated poor Th2/1 responses and restricted parasite fecundity more efficiently. These findings suggest that Th2/1 hybrid responses take part in immune regulation during helminth infection and restrain effective anti-helminth immunity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bazo
/
Nematospiroides dubius
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Interferón gamma
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Infecciones por Strongylida
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Células Th2
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Células TH1
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Intestinos
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania